Endocrine Abstracts

It is well recognised that the intestinal epithelium has a remarkable capacity to regenerate after high levels of DNA damage or injury. Although the kinetics of this ‘clonogenic repopulation’ whereby a new stem cell repopulates the crypt is understood, little is known about the molecular mechanism underlying this, although upregulation of Musashi-1 is known to mark the process. By conditionally deleting genes that are lethal to the intestinal stem cells we have mimic...